CovidFranceV1, Main, Exploration, bibRecord, 001324

Clinical phenotypes of SARS-CoV-2: implications for clinicians and researchers.

Identifieur interne : 001324 ( Main/Exploration ); précédent : 001323; suivant : 001325

Clinical phenotypes of SARS-CoV-2: implications for clinicians and researchers.

Auteurs : Jordi Rello [Espagne, France] ; Enrico Storti [Italie] ; Mirko Belliato [Italie] ; Ricardo Serrano [Espagne]

Source :

The European respiratory journal [ 1399-3003 ] ; 2020.

RBID : pubmed:32341111

Descripteurs français

KwdFr :
- Betacoronavirus (génétique), Compliance pulmonaire (génétique), Femelle (MeSH), Humains (MeSH), Hypoxie (diagnostic), Hypoxie (étiologie), Infections à coronavirus (génétique), Infections à coronavirus (thérapie), Lésion pulmonaire aigüe (physiopathologie), Lésion pulmonaire aigüe (thérapie), Lésion pulmonaire aigüe (virologie), Marqueurs biologiques (sang), Mâle (MeSH), Pandémies (MeSH), Phénotype (MeSH), Pneumopathie virale (génétique), Pneumopathie virale (thérapie), Prise en charge de la maladie (MeSH), Procalcitonine (métabolisme), Recherche biomédicale (MeSH), Virus du SRAS (génétique), Virus du SRAS (pathogénicité).
MESH :
- diagnostic : Hypoxie.
- génétique : Betacoronavirus, Compliance pulmonaire, Infections à coronavirus, Pneumopathie virale, Virus du SRAS.
- métabolisme : Procalcitonine.
- pathogénicité : Virus du SRAS.
- physiopathologie : Lésion pulmonaire aigüe.
- sang : Marqueurs biologiques.
- thérapie : Infections à coronavirus, Lésion pulmonaire aigüe, Pneumopathie virale.
- virologie : Lésion pulmonaire aigüe.
- étiologie : Hypoxie.
- Femelle, Humains, Mâle, Pandémies, Phénotype, Prise en charge de la maladie, Recherche biomédicale.

English descriptors

KwdEn :
- Acute Lung Injury (physiopathology), Acute Lung Injury (therapy), Acute Lung Injury (virology), Betacoronavirus (genetics), Biomarkers (blood), Biomedical Research (MeSH), Coronavirus Infections (genetics), Coronavirus Infections (therapy), Disease Management (MeSH), Female (MeSH), Humans (MeSH), Hypoxia (diagnosis), Hypoxia (etiology), Lung Compliance (genetics), Male (MeSH), Pandemics (MeSH), Phenotype (MeSH), Pneumonia, Viral (genetics), Pneumonia, Viral (therapy), Procalcitonin (metabolism), SARS Virus (genetics), SARS Virus (pathogenicity).
MESH :
- chemical , blood : Biomarkers.
- diagnosis : Hypoxia.
- etiology : Hypoxia.
- genetics : Betacoronavirus, Coronavirus Infections, Lung Compliance, Pneumonia, Viral, SARS Virus.
- chemical , metabolism : Procalcitonin.
- pathogenicity : SARS Virus.
- physiopathology : Acute Lung Injury.
- therapy : Acute Lung Injury, Coronavirus Infections, Pneumonia, Viral.
- virology : Acute Lung Injury.
- Biomedical Research, Disease Management, Female, Humans, Male, Pandemics, Phenotype.

Abstract

Patients with COVID-19 present a broad spectrum of clinical presentation. Whereas hypoxaemia is the marker of severity, different strategies of management should be customised to five specific individual phenotypes. Many intubated patients present with phenotype 4, characterised by pulmonary hypoxic vasoconstriction, being associated with severe hypoxaemia with "normal" (>40 mL·cmH₂O^-1) lung compliance and likely representing pulmonary microvascular thrombosis. Phenotype 5 is often associated with high plasma procalcitonin and has low pulmonary compliance, Which is a result of co-infection or acute lung injury after noninvasive ventilation. Identifying these clinical phenotypes and applying a personalised approach would benefit the optimisation of therapies and improve outcomes.

DOI: 10.1183/13993003.01028-2020
PubMed: 32341111
PubMed Central: PMC7236837

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 001565
to stream Main, to step Curation: 001565

Le document en format XML

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<term>Betacoronavirus (genetics)</term>
<term>Biomarkers (blood)</term>
<term>Biomedical Research (MeSH)</term>
<term>Coronavirus Infections (genetics)</term>
<term>Coronavirus Infections (therapy)</term>
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<term>Humans (MeSH)</term>
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<term>Lung Compliance (genetics)</term>
<term>Male (MeSH)</term>
<term>Pandemics (MeSH)</term>
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<term>Pneumonia, Viral (genetics)</term>
<term>Pneumonia, Viral (therapy)</term>
<term>Procalcitonin (metabolism)</term>
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<term>Compliance pulmonaire (génétique)</term>
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<term>Humains (MeSH)</term>
<term>Hypoxie (diagnostic)</term>
<term>Hypoxie (étiologie)</term>
<term>Infections à coronavirus (génétique)</term>
<term>Infections à coronavirus (thérapie)</term>
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<term>Pneumopathie virale (thérapie)</term>
<term>Prise en charge de la maladie (MeSH)</term>
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<term>Pandemics</term>
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<term>Mâle</term>
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<front><div type="abstract" xml:lang="en">Patients with COVID-19 present a broad spectrum of clinical presentation. Whereas hypoxaemia is the marker of severity, different strategies of management should be customised to five specific individual phenotypes. Many intubated patients present with phenotype 4, characterised by pulmonary hypoxic vasoconstriction, being associated with severe hypoxaemia with "normal" (>40 mL·cmH<sub>2</sub>
O<sup>-1</sup>
) lung compliance and likely representing pulmonary microvascular thrombosis. Phenotype 5 is often associated with high plasma procalcitonin and has low pulmonary compliance, Which is a result of co-infection or acute lung injury after noninvasive ventilation. Identifying these clinical phenotypes and applying a personalised approach would benefit the optimisation of therapies and improve outcomes.</div>
</front>
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<DateCompleted><Year>2020</Year>
<Month>06</Month>
<Day>03</Day>
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<DateRevised><Year>2020</Year>
<Month>06</Month>
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<ArticleTitle>Clinical phenotypes of SARS-CoV-2: implications for clinicians and researchers.</ArticleTitle>
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<Abstract><AbstractText>Patients with COVID-19 present a broad spectrum of clinical presentation. Whereas hypoxaemia is the marker of severity, different strategies of management should be customised to five specific individual phenotypes. Many intubated patients present with phenotype 4, characterised by pulmonary hypoxic vasoconstriction, being associated with severe hypoxaemia with "normal" (>40 mL·cmH<sub>2</sub>
O<sup>-1</sup>
) lung compliance and likely representing pulmonary microvascular thrombosis. Phenotype 5 is often associated with high plasma procalcitonin and has low pulmonary compliance, Which is a result of co-infection or acute lung injury after noninvasive ventilation. Identifying these clinical phenotypes and applying a personalised approach would benefit the optimisation of therapies and improve outcomes.</AbstractText>
<CopyrightInformation>Copyright ©ERS 2020.</CopyrightInformation>
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<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rello</LastName>
<ForeName>Jordi</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Centro de Investigación Biomedica en Red (CIBERES), Instituto de Salud Carlos III, Madrid, Spain jrello@crips.es.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>CRIPS, Vall d'Hebron Institute of Research, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Clinical Research, CHU Nîmes, Université Montpellier-Nîmes, Nîmes, France.</Affiliation>
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<Author ValidYN="Y"><LastName>Storti</LastName>
<ForeName>Enrico</ForeName>
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<AffiliationInfo><Affiliation>Anesthesia and ICU Dept, Hospitale de Lodi, Lodi, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Belliato</LastName>
<ForeName>Mirko</ForeName>
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<Author ValidYN="Y"><LastName>Serrano</LastName>
<ForeName>Ricardo</ForeName>
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<AffiliationInfo><Affiliation>Critical Care Dept, Hospital de Hellin, Albacete, Spain.</Affiliation>
</AffiliationInfo>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D055371" MajorTopicYN="N">Acute Lung Injury</DescriptorName>
<QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
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<MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName>
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<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
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<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
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<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000860" MajorTopicYN="N">Hypoxia</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008170" MajorTopicYN="N">Lung Compliance</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010641" MajorTopicYN="Y">Phenotype</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000077740" MajorTopicYN="N">Procalcitonin</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName>
</MeshHeading>
</MeshHeadingList>
<CoiStatement>Conflict of interest: J. Rello has nothing to disclose. Conflict of interest: E. Storti has nothing to disclose. Conflict of interest: M. Belliato reports personal fees for lectures from Hamilton Medical, Swiss and Bonaduz, outside the submitted work. Conflict of interest: R. Serrano has nothing to disclose.</CoiStatement>
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<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>04</Month>
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Clinical phenotypes of SARS-CoV-2: implications for clinicians and researchers.

Clinical phenotypes of SARS-CoV-2: implications for clinicians and researchers.

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